Kimberly Raab-Graham

Kimberly Raab-Graham, PhD Principal Investigator

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Where to find us:
Piedmont Triad Community Research Center
115 S Chestnut St., Room 280
Winston-Salem, NC 27101
336-716-8583

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mTORC1 regulation of protein synthesis, synaptic tagging, and neuronal excitability:

 

Niere F, Raab-Graham KF.
mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.
Front Cell Neurosci. 2017 May 30;11:152. doi: 10.3389/fncel.2017.00152. eCollection 2017.
PMID:28611595

 

Raab-Graham KF, Niere F.
mTOR referees memory and disease through mRNA repression and competition.
FEBS Lett. 2017 Jun;591(11):1540-1554. doi: 10.1002/1873-3468.12675. Epub 2017 May 27. Review.
PMID:28493559

 

Namjoshi SV, Raab-Graham KF.
Screening the Molecular Framework Underlying Local Dendritic mRNA Translation.
Front Mol Neurosci. 2017 Feb 24;10:45. doi: 10.3389/fnmol.2017.00045. eCollection 2017. Review.
PMID:28286470

 

Niere F*, Namjoshi S*, Song E, Dilly GA, Schoenhard G, Zemelman BV, Mechref Y, Raab-Graham KF.
Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC).
Mol Cell Proteomics. 2016 Feb;15(2):426-44. doi: 10.1074/mcp.M115.055079. Epub 2015 Sep 29.

PMID:26419955

*authors contributed equally

 

Sosanya NM, Cacheaux LP, Workman ER, Niere F, Perrone-Bizzozero NI, Raab-Graham KF.
Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD.
J Biol Chem. 2015 Jun 26;290(26):16357-71. doi: 10.1074/jbc.M114.599399. Epub 2015 May 5.

PMID:25944900

One of the top 5 most viewed articles at the Journal of Biological Chemistry in May and June, 2015

 

Sosanya NM, Brager DH, Wolfe S, Niere F, Raab-Graham KF.
Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis.
Neurobiol Dis. 2015 Jan;73:96-105. doi: 10.1016/j.nbd.2014.09.011. Epub 2014 Sep 28.

PMID:25270294

 

Sosanya NM, Huang PP, Cacheaux LP, Chen CJ, Nguyen K, Perrone-Bizzozero NI, Raab-Graham KF.
Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.
J Cell Biol. 2013 Jul 8;202(1):53-69. doi: 10.1083/jcb.201212089.

PMID:23836929

Highlighted in Journal of Cell Biology (Kepert, I. and Kiebler, M.A. (2013) monitTORing neuronal excitability at the synapse, Journal of Cell Biology, 202, 7-9.

 

Raab-Graham KF*, Haddick PC*, Jan YN, Jan LY.
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
Science. 2006 Oct 6;314(5796):144-8.

PMID:17023663

        *authors contributed equally

Highlighted in Editors’ Choice (Sci. STKE 356:348, 2006)

Highlighted in Previews (Neuron 52:399-401, 2006).

Highlighted in “Highlights from the Literature” (Physiology 21:3-6, 2007)

 

Underlying mechanisms of rapid antidepressant therapies:

 

Workman ER, Niere F, Raab-Graham KF.
Engaging homeostatic plasticity to treat depression.
Mol Psychiatry. 2018 Jan;23(1):26-35. doi: 10.1038/mp.2017.225. Epub 2017 Nov 14.
PMID:29133952

 

Wolfe SA, Workman ER, Heaney CF, Niere F, Namjoshi S, Cacheaux LP, Farris SP, Drew MR, Zemelman BV, Harris RA, Raab-Graham KF.

FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties.
Nat Commun. 2016 Sep 26;7:12867. doi: 10.1038/ncomms12867.
PMID: 27666021

 

Raab-Graham KF, Workman ER, Namjoshi S, Niere F.
Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression.
Brain Res. 2016 Apr 26. pii: S0006-8993(16)30215-3. doi: 10.1016/j.brainres.2016.04.020. [Epub ahead of print] Review.

PMID:27125595

 

Workman ER, Haddick PC, Bush K, Dilly GA, Niere F, Zemelman BV, Raab-Graham KF.
Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η.
Mol Psychiatry. 2015 Mar;20(3):298-310. doi: 10.1038/mp.2014.165. Epub 2015 Jan 6.

PMID:25560757

Invited Cover

Workman and Raab-Graham cover2

 

Workman ER, Niere F, Raab-Graham KF.
mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling.
Neuropharmacology. 2013 Oct;73:192-203. doi: 10.1016/j.neuropharm.2013.05.037. Epub 2013 Jun 8.

PMID:23752093